Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs

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Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

Bone morphogenic proteins (BMPs) are universal regulators of animal development. We report the identification and cloning of the BMP type II receptor (BMPR-II), a missing component of this receptor system in vertebrates. BMPR-II is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I, which ...

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 1995

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.15.7.3479